Research Scientist, Liver Disease

Research Scientist, Liver Disease

About the role:

At Takeda, we are a forward-looking, world-class R&D organization that unlocks innovation and delivers transformative therapies to patients. By focusing R&D efforts on three therapeutic areas and other targeted investments, we push the boundaries of what is possible in order to bring life-changing therapies to patients worldwide.

Join Takeda as a Research Scientist, Liver Disease Research where you will be part of a team focused on validation of novel targets and the evaluation of drug candidates for the treatment of chronic fibroinflammatory liver diseases.

How you will contribute:

• You will apply expertise in executing in vitro studies relevant to fibroinflammatory liver disease biology and pharmacology.
• You will play a central role in generating key data for evaluating potential targets, mechanism of action and/or drug candidate efficacy and pharmacodynamics.
• You will need to be a highly collaborative and energetic team player and a self-directed learner with a keen interest in focused, fast-paced research.
• Designs and executes relevant target and drug candidate validation studies using contemporary methods and tools.
• Using a broad range of technologies, determine mechanism of action for drug targets and candidates with appropriate controls
• Implement target-specific assays to assess target and drug activity in vitro and/or in vivo, as appropriate
• Identifies orthogonal applications of target, pathway, or platform biology in other fibroinflammatory diseases
• Participate on cross-functional teams and provide technical leadership in area of expertise; may lead an initiative or one of a broader scope with a less-defined outcome
• Prepare technical reports, summaries, protocols, and quantitative analyses in written and/or oral form
• Proactively identify complex obstacles to progress in specific areas; recommend and implement solutions using a diverse set of resources; regularly add value to research projects through creative ideas
• Manage a wide variety of tasks, techniques, and projects; integrate these responsibilities to produce quality result with a high level of efficiency; may act as a scientific mentor to others
• Keep an accurate, comprehensible, concise notebook in accordance with company policy
• Maintain lab equipment and supplies as needed
• Maintain a safe and organized lab bench
• Communicate with colleagues effectively
• Present data to other scientific staff or cross-functional project team; may present data/posters to external research or scientific community.

Minimum Requirements/Qualifications:

• PhD degree in a scientific discipline (or equivalent), or
  MS with 6+ years relevant experience, or BS with 8+ years relevant experience in vitro drug discovery research

• Demonstrated ability to independently solve scientific problems using multiple, state-of-the-art technologies and approaches 
• Significant experience with drug discovery applications of cell culture including immortalized cell lines, primary cell cultures, and multicellular or organoid culture models, preferably models that recapitulate cellular cross-talk in fibroinflammatory or diseased tissues
• Expertise in at least one of the following assay methods: ELISA, Western blot, qPCR, flow cytometry, ChIP

• Experience and continued willingness to work with live rodents and animal tissue

• Demonstrates exceptional project management skills and in-depth in vitro cell and molecular biology assay experience  

The estimated salary range reflects an anticipated range for this position. The actual base salary offered may depend on a variety of factors, including the qualifications of the individual applicant for the position, years of relevant experience, specific and unique skills, level of education attained, certifications or other professional licenses held, and the location in which the applicant lives and/or from which they will be performing the job.The actual base salary offered will be in accordance with state or local minimum wage requirements for the job location.

U.S. based employees may be eligible for short-term and/or long-termincentives. U.S.based employees may be eligible to participate in medical, dental, vision insurance, a 401(k) plan and company match, short-term and long-term disability coverage, basic life insurance, a tuition reimbursement program, paid volunteer time off, company holidays, and well-being benefits, among others. U.S.based employees are also eligible to receive, per calendar year, up to 80 hours of sick time, and new hires are eligible to accrue up to 120 hours of paid vacation.