Research Associate Scientist, Investigative Toxicology

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Job Description

OBJECTIVES: 

The Global Investigative Toxicology team is a cross-functional team of scientists that aim to detect and de-risk toxicity in Takeda’s portfolio to help make medicines safer and more effective. We are looking for a Research Associate Scientist to support these efforts across small molecule, biologics and cell therapy platforms. The Research Associate Scientist will contribute ideas and deliver decision-making data to inform design and prioritization of drug candidates.

• Work as part of a global team of safety assessment scientists to detect and de-risk toxicities associated various modalities
• Design and implement early safety assessment screening strategies to enable the progression of optimized therapeutic candidates
• Conduct cell-based in vitro assays to characterize immune-mediated toxicities for medicines in discovery & development
• Develop novel in vitro model systems to assess safety risks associated with new therapeutic designs

ACCOUNTABILITIES: 

• Develop, design, execute, and interpret in vitro cell-based assays to characterize diverse mechanisms of drug candidates
• Maintain cultures of immortalized tumor cell lines, primary cell types of various origin (lung, liver, kidney, intestine, pancreas, etc.), and primary immune cells (T cells, B cells, NK cells, etc.)
• Perform fit-for-purpose ex vivo analyses to assess phenotypic and functional correlates of toxicity
• Prepare experimental protocols, analyze experimental data, and present study results in team and department meetings
• Contribute ideas to drive innovation within investigative toxicology and with key collaborators (e.g. pharmacology, DMPK, bioinformatics)
• Document experimental methods and findings in electronic laboratory notebook

EDUCATION, BEHAVIOURAL COMPETENCIES AND SKILLS:

• MS. with 3+ years or BS with 5+ years of experience in immunology, biology, biochemistry, pharmacology, or a related discipline.
• Expert with standard aseptic cell culture technique, including experience culturing various tumor cell lines and primary cells. 
• Broad experience with cell-based functional assays, including cytotoxicity, cytokine release, and proliferation assays. Experience with flow cytometry is highly preferred.
• Basic experience with molecular biology techniques including RNA/DNA extraction, qPCR, western blot
• Experience working in a matrixed team environment at a pharmaceutical company and/or CRO
• Broad scientific knowledge in immunology and pharmacology
• Self-motivated with strong time management and organizational skills
• Ability to balance multiple projects and flexible with changing priorities
• Highly collaborative with demonstrated ability to work in a matrixed team environment
• Excellent oral and written communication skills

LICENSES/CERTIFICATIONS:

PHYSICAL DEMANDS: 

• Routine demands of an office based environment.

TRAVEL REQUIREMENTS:

• Ability to travel domestically and internationally, <5%

Takeda Compensation and Benefits Summary

We understand compensation is an important factor as you consider the next step in your career. We are committed to equitable pay for all employees, and we strive to be more transparent with our pay practices.

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EEO Statement

Takeda is proud in its commitment to creating a diverse workforce and providing equal employment opportunities to all employees and applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, gender expression, parental status, national origin, age, disability, citizenship status, genetic information or characteristics, marital status, status as a Vietnam era veteran, special disabled veteran, or other protected veteran in accordance with applicable federal, state and local laws, and any other characteristic protected by law.

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