Research Associate Scientist, Inflammation Discovery Research

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Job Description

At Takeda, we are a forward-looking, world-class R&D organization that unlocks innovation and delivers transformative therapies to patients. By focusing R&D efforts on three therapeutic areas and other targeted investments, we push the boundaries of what is possible to bring life-changing therapies to patients worldwide.

About the Role:

The Gastrointestinal and Inflammation (GI2) Drug Discovery Unit at Takeda is building a new team of experienced, innovative, and collaborative researchers to deliver an industry-leading portfolio of drugs for various gastrointestinal, autoimmune, and inflammatory diseases with high unmet medical needs. We seek a Research Associate Scientist to join our biology and cross-functional discovery teams and create novel drug candidates.

• Generate and execute preclinical development strategies to support candidate selection, facilitating efficient clinical validation of impactful medicines for patients with inflammatory disorders.
• Apply deep scientific and technical expertise in immunology and/or cell biology to creatively mature innovative novel concepts within our team, in matrixed collaboration with other Takeda scientists, and external partners. 
• Drive an inclusive, open, and effective culture in a fast-growing drug discovery group.

Accountabilities:                                        

• Generate data packages supporting candidate selection and asset characterization based on current in vitro methods including immortalized cell lines, primary cell cultures, and multicellular or organoid culture models, preferably models that recapitulate cellular cross-talk in fibroinflammatory or diseased tissues
• Champion scientific integrity and rigor in preparation and interpretation of detailed protocols/SOPs.
• Independently plans assignments for a research work group or project, troubleshoots complex problems specialized procedures, and change experimental design if necessary.
• Develops and validates new methods to support completion of complex assignments within a project
• Exercises independent judgment (selecting most appropriate methods, coordinating efforts, evaluating criteria for obtaining results)
• Utilizes technical literature to implement novel procedures, changes, and improvements within a project. Can duplicate and appropriately modify experimental procedures based on the literature.
• Interprets and analyzes data, helping to incorporate results into overall scientific projects; Independently generates novel hypotheses
• Maintains a proactive and vocal approach to improving departmental efficiency;
• Able to summarize and present literature data within the department and occasionally to a broader audience

Education & Competencies (Technical and Behavioral):

• MS in a scientific discipline with 3+ years’ experience, or BS with 5+ years’ experience
• Expertise in at least one of the following assay methods: ELISA/MSD, Western blot, qPCR, flow cytometry, ChIP
• Experience with cell culture, including isolation, culture, and analysis of primary immune cell subsets
• Direct experience with the principles, models, and pathways of autoimmunity, inflammation, and/or fibrosis
• Experience developing and/or evaluating small molecule, biologic and/or nucleic acid therapeutics
• Demonstrates strong organizational and project management skills and effective written and verbal communication skills. 
• Preferred: familiarity with in vivo study design/execution; modern high-dimensional gene expression analysis (i.e., scRNAseq); multicellular culture systems (i.e., organoids)

This position is currently classified as “onsite” in Cambridge, MA.

Takeda Compensation and Benefits Summary

We understand compensation is an important factor as you consider the next step in your career. We are committed to equitable pay for all employees, and we strive to be more transparent with our pay practices.

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EEO Statement

Takeda is proud in its commitment to creating a diverse workforce and providing equal employment opportunities to all employees and applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, gender expression, parental status, national origin, age, disability, citizenship status, genetic information or characteristics, marital status, status as a Vietnam era veteran, special disabled veteran, or other protected veteran in accordance with applicable federal, state and local laws, and any other characteristic protected by law.

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