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Associate Director, Human Genetics

Boston, Massachusetts
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  • Job Type: Full Time
  • Job Level: Senior
  • Travel: Minimal (if any)

At Takeda, we strive to provide transformational opportunities for every member of our team, and we empower our people to take charge of their futures. In an environment that fosters lifelong learning and a growth mindset, you’ll have the support you need to thrive — at work and beyond.

Job ID R0133632 Date posted 10/28/2024 Location Boston, Massachusetts

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Job Description

About the role:

At Takeda, we are a forward-looking, world-class R&D organization that unlocks innovation and delivers transformative therapies to patients. By focusing R&D efforts on three therapeutic areas and other targeted investments, we push the boundaries of what is possible in order to bring life-changing therapies to patients worldwide.

Are you looking for a patient-focused, innovation-driven company that will inspire you and empower you to shine? Join us as Senior Scientist, Human Genetics in our Cambridge, Massachusetts office. The Human Genetics team in Takeda Research is responsible for generating impactful insights from human genetics data to advance Takeda’s pipeline across Gastrointestinal & Inflammatory diseases, Neurosciences and Oncology disease areas. We are seeking an innovative data scientist with deep knowledge in human genetics and multi-omics to join our team and accelerate drug target discovery.

In this critical role, you will lead human genetics projects from ideation to execution, using publicly available and proprietary data, to advance target identification and validation, safety assessment, and patient stratification. This role’s responsibilities include 1) key contributions to establishing the Human Genetics group strategy, 2) close collaboration with colleagues in various functions across the organization to drive impact and contribute to go-no go decisions across Takeda’s drug discovery and development pipeline, and 3) active contributions to external collaborations to link genetic data to longitudinal phenotypic data from diverse populations. You will be empowered to work closely with disease area leads to identify priorities and design human genetic analyses. This is an amazing opportunity to work in an inclusive and highly collaborative cross-functional workplace driven by one mission: drive the science forward to deliver transformative therapies to patients.

How you will contribute:

ACCOUNTABILITIES

  • Establish an influential and collaborative role within disease-oriented project teams by leading and actively contributing to the design, analysis and interpretation of genetic studies to inform target identification, safety assessment and population stratification in Gastrointestinal & Inflammatory diseases, Neurosciences.
  • Work with a community of statistical geneticists to implement a human genetics roadmap and strategy.
  • Work collaboratively with data scientists and data engineering groups to enhance integrative analytic pipelines
  • Establish and lead external collaborations to implement emerging technologies and/or interrogate relevant biomedical datasets with in-depth genetic and health information

Minimum Requirements/Qualifications:

  • PhD in computational biology, bioinformatics or similar discipline with 6+ years of postdoctoral experience in human genetics research. Industry experience preferred.
  • Deep experience with GWAS/eQTL/pQTL analyses, fine-mapping and colocalization, Mendelian randomization, WES/WGS sequencing data analyses, and rare variants statistical analyses required.
  • Track record experience analyzing genetic data linked to longitudinal real-world health data from large biobanks (e.g. UK Biobank, FINNGEN, Genes and Health, All Of Us, Million Veterans Project etc) required
  • Experience contributing to pre-competitive academic-pharma partnerships preferred.
  • Experience with proteomics (e.g  Olink) and/or transcriptomic data analyses desired.
  • Experience with phenotype ontologies, pathway-based approaches, multivariate analyses, polygenic risk score analyses, machine learning desired.
  • Strong scientific understanding of molecular biology and genomics, and ability to interpret genetic findings in disease context
  • Familiarity with pharmaceutical R&D processes and one or more diseases areas of interest of Takeda (neuroscience, gastrointestinal and inflammation) desired 
  • Excellent communication, presentation and interpersonal skills
  • Independent, highly collaborative with ability to work in cross-functional and diverse team environment
  • Solid knowledge of Unix, command lines interfaces, and fluency in common scripting and/or programming language (e.g. R, Python, Perl, Java, C/C++)
  • Solid experience with parallel computing and cloud computing required

This position is currently classified as "hybrid" in accordance with Takeda's Hybrid and Remote Work policy.

LOCATION:

Location: Cambridge, MA, USA (hybrid)

Takeda Compensation and Benefits Summary

We understand compensation is an important factor as you consider the next step in your career. We are committed to equitable pay for all employees, and we strive to be more transparent with our pay practices.

For Location:

Boston, MA

U.S. Base Salary Range:

$149,100.00 - $234,300.00

The estimated salary range reflects an anticipated range for this position. The actual base salary offered may depend on a variety of factors, including the qualifications of the individual applicant for the position, years of relevant experience, specific and unique skills, level of education attained, certifications or other professional licenses held, and the location in which the applicant lives and/or from which they will be performing the job.The actual base salary offered will be in accordance with state or local minimum wage requirements for the job location.

U.S. based employees may be eligible for short-term and/or long-termincentives. U.S.based employees may be eligible to participate in medical, dental, vision insurance, a 401(k) plan and company match, short-term and long-term disability coverage, basic life insurance, a tuition reimbursement program, paid volunteer time off, company holidays, and well-being benefits, among others. U.S.based employees are also eligible to receive, per calendar year, up to 80 hours of sick time, and new hires are eligible to accrue up to 120 hours of paid vacation.

EEO Statement

Takeda is proud in its commitment to creating a diverse workforce and providing equal employment opportunities to all employees and applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, gender expression, parental status, national origin, age, disability, citizenship status, genetic information or characteristics, marital status, status as a Vietnam era veteran, special disabled veteran, or other protected veteran in accordance with applicable federal, state and local laws, and any other characteristic protected by law.

Locations

Boston, MA

Worker Type

Employee

Worker Sub-Type

Regular

Time Type

Full time
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Where you fit in

Our team at Takeda is tackling some of the most challenging problems in drug discovery and development. As the newest member of our Research team, you’ll conduct purposeful, meaningful work on groundbreaking modalities that may lead to breakthrough drugs.

With our deep investment in next-generation technologies, you’ll have the resources and support to do your best work. As a part of our team, you’ll connect with brilliant minds inside and outside of Takeda. We are committed to collaborating with academia and emerging biotech companies to expand our reach and impact in cell therapy, gene therapy and data sciences.

Our team’s wide-ranging expertise includes medicinal chemistry, genomics datasets, immunofluorescence, high content imaging, flow cytometry, transcriptional profiling, multi-step synthesis, multimodal genetics, pharmacokinetics and much more. Whatever area inspires you, your work will support the progression of an innovative, industry-leading discovery pipeline and make an impact that matters to patients and society.

A career in Research at Takeda will give you everything you need to succeed professionally — and make a difference to patients, people and the planet.

  • Design and carry out experiments

  • Manage multiple projects

  • Document data

  • Mentor other scientists

Along with incredibly passionate colleagues, there’s a clear commitment to invest in the best facilities and the right equipment needed to successfully perform world-class science.

Christina Alves - Head of Biotherapeutics Process Development

Our pipeline

Our internal research capabilities and external partnerships contribute to an R&D engine that has produced exciting new molecular entities (NMEs) across our core Therapeutic Areas. Check out our pipeline and see how we’ll continue delivering a steady stream of next-generation therapies.

Learn more

What we believe in

Our values of Takeda-ism are Integrity, Fairness, Honesty and Perseverance, with Integrity as the core. These are brought to life through actions based on Patient, Trust, Reputation and Business, in that order.

Our belief in putting people first extends beyond our patients — it includes their families and communities, as well as our Takeda colleagues and their families.

We are committed to embracing our differences, valuing different perspectives, and fostering a culture of respect, inclusiveness and empowerment.

Our embedded Diversity, Equity & Inclusion (DE&I) strategy enables us to attract and retain exceptional talent, drives innovation, and helps address systemic inequalities in our communities.

  • Integrity

  • Fairness

  • Honesty

  • Perseverance

Working at Takeda

  • Inclusion

    Here, you will feel welcomed, respected, and valued as a vital contributor to our global team.
  • Collaboration

    A strong, borderless team, we strive together towards our priorities and inspiring mission.
  • Innovation

    Bold initiatives, continuous improvement, and creativity are at the heart of how we bring scientific breakthroughs from the lab to patients.
  • Top Workplace

    Recognized for our culture and way of working, we’re one of only 17 companies to receive Top Global Employer® status for 2024.
  • Work-Life

    Our people-first mission extends beyond patients to include their families, communities, and our own Takeda family.
  • Empowerment

    Through trust and respect, you will have genuine support from leaders, managers, and colleagues to do your best work.

We're Steadfast In Our Commitment to Four Key Imperatives

Patient


Responsibly translate science into highly innovative medicines and accelerate access to improve lives worldwide.

People


Create an exceptional people experience.

Planet


Protect our planet.

Data & Digital


Transform Takeda into the most trusted, data-driven, outcomes-based biopharmaceutical company.

Exterior of Takeda Building

About our location

Boston, Massachusetts


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